Зонды Cancer NBC768 — Онкологическая панель на 700+ генов (1.3 Мб), 96 реакций

Cancer NBC768 Panel — это жидкофазная панель зондов для таргетного секвенирования более 700 генов, включая полные экзонные области 324 ключевых онкогенов и дополнительные горячие участки (внутрины, промоторы, UTR). Общий целевой размер составляет ~1.3 Mb. Панель предназначена для всестороннего анализа точечных мутаций, инделов, перестроек и вариаций числа копий, что делает её подходящей для клинической диагностики и исследований в онкологии. Разработана с учетом баланса между глубиной анализа и стоимостью — оптимальна для жидкостной биопсии и FFPE-образцов.

Список генов:
ABCA4, ABCB1, ABCC2, ABCG2, ABL1, ABL2, ACTC1, ACTG1, ACVR1, ACVR1B, ACVR2A, ACYP2, ADGRA2, ADGRG6, ADORA2A, AFF3, AGO2, AJUBA, AKAP9, AKT1, AKT2, AKT3, ALK, ALOX12B, AMER1, ANKRD11, ANKRD26, APC, AQP7, AR, ARAF, ARFRP1, ARID1A, ARID5B, ARSA, ARVCF, ASPM, ASXL1, ASXL2, ATAD3B, ATIC, ATM, ATP6V1B2, ATP7B, ATR, ATRX, ATXN7L1, AURKA, AURKB, AXIN1, AXIN2, AXL, B9D2, BABAM1, BAP1, BARD1, BAX, BBC3, BCL10, BCL11A, BCL2, BCL2A1, BCL2L1, BCL2L2, BCL6, BCL9, BCOR, BCORL1, BCR, BEST1, BIRC2, BIRC3, BRAF, BRCA1, BRCA2, BRD3, BRD4, BRIP1, BTBD9, BTG1, BTG2, BTK, BUB1B, C8orf34, CA12, CALR, CANT1, CARD11, CARD8, CARM1, CASP2, CASP7, CASP8, CBFB, CBL, CBLB, CBR3, CC2D2A, CCN6, CCND1, CCND2, CCND3, CCNE1, CCNQ, CD22, CD274, CD276, CD58, CD70, CD74, CD79A, CD79B, CDA, CDC42SE2, CDC73, CDH1, CDK12, CDK2, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDX2, CEBPA, CENPA, CEP72, CHD1, CHD2, CHD4, CHEK1, CHEK2, CHRNA4, CIC, CLSTN2, CNGA1, COL4A5, COMT, COP1, CP, CREBBP, CRKL, CRLF2, CSDE1, CSF1, CSF1R, CSF2, CSF3, CSF3R, CSMD3, CSNK1A1, CTCF, CTLA4, CTNNA1, CTNNB1, CTR9, CUBN, CUL3, CUL4A, CUX1, CXCR2, CXCR4, CYP17A1, CYP19A1, CYP1A1, CYP1B1, CYP2B6, CYP2C19, CYP2C8, CYP2D6, CYP3A5, CYP4B1, CYP4V2, CYSLTR2, D13S317, D17S250, D17S261, D17S799, D18S34, D1S2883, D2S123, D5S346, DAXX, DCUN1D1, DDB2, DDC, DDR1, DDR2, DDX41, DHFR, DHX15, DIS3, DKC1, DNAJB1, DNMT1, DNMT3A, DNMT3B, DOT1L, DPYD, DROSHA, DSCAM, DTX1, DUSP22, DUSP4, E2F3, EED, EGFR, EIF1AX, EIF4A2, ELF3, ELOC, EMSY, EP300, EP400, EPAS1, EPHA3, EPHA5, EPHA7, EPHB1, EPHB2, EPHB4, EPOR, ERBB2, ERBB3, ERBB4, ERCC1, ERCC2, ERCC4, ERCC5, ERCC6, ERCC8, ERF, ERG, ERICH1, ERRFI1, ESCO2, ESR1, ESR2, ETS1, ETV1, ETV4, ETV5, ETV6, EWSR1, EXT1, EXT2, EZH1, EZH2, EZR, FAM161A, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FAT1, FAT3, FAT4, FBXW7, FCGR2B, FCGR3A, FGF1, FGF10, FGF12, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FH, FLCN, FLI1, FLT1, FLT3, FLT4, FOXF1, FOXL2, FOXO1, FOXO3, FOXP1, FRS2, FUBP1, FURIN, FYN, GAB2, GABRA6, GALT, GAS7, GATA3, GATA4, GATA6, GEN1, GFRA2, GID4, GLI1, GNA11, GNA13, GNAQ, GNAS, GNB1, GPC3, GRM3, GSE1, GSK3B, GSTM1, GSTP1, GSTT1, H2AC11, H2AC16, H2BC4, H3-3A, H3-3B, H3-4, H3C1, H3C10, H3C11, H3C2, H3C3, H3C4, H3C6, H3C8, HAS3, HDAC1, HDAC2, HDAC6, HGD, HGF, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-E, HLA-F, HLA-G, HMGA1, HNF1A, HNRNPK, HOXB13, HRAS, HSD3B1, HSP90AA1, HSP90AB1, HSPA4, HSPH1, ID3, IDH1, IDH2, IDUA, IFNGR1, IGF1, IGF1R, IGF2R, IKBKE, IKZF1, INHA, INHBA, INPP4A, INPP4B, INPPL1, INSR, IRF1, IRF2, IRF4, IRF8, IRS1, IRS2, JAK1, JAK2, JAK3, JARID2, JUN, KANK1, KAT6A, KAT6B, KCNA1, KCNJ12, KCNQ3, KDM5A, KDM5C, KDM6A, KDR, KDSR, KEAP1, KEL, KIF1B, KIF5B, KIT, KLF4, KLHL6, KMT2A, KMT2B, KMT2C, KMT2D, KMT5A, KNSTRN, KRAS, KSR2, LAMP1, LATS1, LATS2, LCK, LIMD1, LINC01924, LINGO2, LMO1, LRP1B, LRP2, LRRC7, LTK, LYL1, LYN, LZTR1, MAF, MAFB, MAGI2, MAML1, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAP3K1, MAP3K13, MAP3K14, MAP3K4, MAP4K3, MAPK1, MAPK3, MAPKAP1, MAST3, MATN3, MCL1, MDC1, MDM2, MDM4, MECOM, MED12, MEF2B, MEN1, MERTK, MET, MGA, MGAM, MINDY4, MITF, MKNK1, MKS1, MLH1, MLH3, MLLT3, MPL, MRE11, MRO, MS4A1, MSH2, MSH3, MSH4, MSH6, MSI1, MSI2, MST1R, MT1X, MTAP, MTHFD1L, MTHFR, MTOR, MTR, MTRR, MUC1, MUTYH, MYB, MYC, MYCL, MYCN, MYD88, MYO18B, MYOD1, MYT1L, NAB2, NBN, NCOA3, NCOR1, NCOR2, NCSTN, NEGR1, NF1, NF2, NFAM1, NFE2L2, NFKB2, NFKBIA, NIN, NKX2-1, NKX3-1, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPC1, NPM1, NPRL3, NQO1, NR-21, NR-22, NRAS, NRG1, NSD1, NSD2, NSD3, NT5C2, NTHL1, NTRK1, NTRK2, NTRK3, NUDT15, NUF2, NUP214, NUP93, NUP98, NUTM1, OFD1, OPRM1, OTC, OTOF, P2RY8, PAK1, PAK3, PAK5, PALB2, PARM1, PARP1, PARP2, PARP3, PAX3, PAX5, PAX7, PAX8, PBRM1, PBX1, PDCD1, PDCD1LG2, PDE4DIP, PDE9A, PDGFRA, PDGFRB, PDHA1, PDK1, PDS5B, PER1, PGR, PHF6, PHOX2B, PIGA, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R3, PIM1, PKHD1, PLAG1, PLCG2, PLK1, PLK2, PMAIP1, PMS2, PNPLA3, PNRC1, POLD1, POLE, POLH, POLR2A, PPARG, PPM1D, PPP2R1A, PPP2R2A, PPP4R2, PPP6C, PRCC, PRDM1, PRDM14, PREX2, PRKAA2, PRKAR1A, PRKCI, PRKD1, PRKDC, PRKN, PROM1, PRSS1, PRSS8, PTCH1, PTCH2, PTEN, PTK2, PTP4A1, PTPN1, PTPN11, PTPN2, PTPRD, PTPRO, PTPRS, PTPRT, PYGL, QKI, RAB35, RAC1, RAC2, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RARA, RASA1, RB1, RBBP8, RBM10, RBMXL1, RECQL, RECQL4, REL, RET, RGPD4, RHBDF2, RHEB, RHOA, RICTOR, RIT1, RNF213, RNF43, ROS1, RPS6KA4, RPS6KB1, RPS6KB2, RPTOR, RRAGC, RRAS, RRAS2, RRM1, RSPO2, RTEL1, RUNX1, RUNX1T1, RXRA, RYBP, RYR2, SAMHD1, SBDS, SCD, SCN3B, SDC4, SDHA, SDHB, SDHC, SDHD, SDK1, SEMA3C, SEMA3E, SERPINB3, SESN2, SESN3, SETBP1, SETD1A, SETD2, SF3B1, SGK1, SH2B3, SH2D1A, SHOC2, SHQ1, SIPA1L2, SLC16A6, SLC19A1, SLC22A2, SLC28A3, SLC34A2, SLC3A2, SLC5A10, SLCO1B1, SLCO1B3, SLIT1, SLX4, SMAD2, SMAD3, SMAD4, SMARCA2, SMARCA4, SMARCB1, SMARCD1, SMC1A, SMC3, SMG1, SMO, SMYD3, SNAPC2, SNCAIP, SOCS1, SOD2, SOS1, SOX10, SOX17, SOX2, SOX9, SPECC1, SPEN, SPOP, SPRED1, SPTA1, SRC, SRD5A2, SRSF2, STAG1, STAG2, STAT3, STAT5A, STAT5B, STIM1, STK11, STK19, SUDS3, SUFU, SV2C, SYK, TAF1, TAF15, TAL1, TAP1, TAP2, TBL1XR1, TBX3, TCF3, TCF4, TCF7L2, TEK, TENT5C, TERC, TERT, TET1, TET2, TET3, TGFBR1, TGFBR2, THADA, TIPARP, TK2, TLK2, TLR7, TLR9, TLX3, TMEM67, TMPRSS13, TMPRSS2, TNFAIP3, TNFRSF14, TNFSF11, TOP1, TOP2A, TP53, TP53BP1, TP63, TPMT, TPSAB1, TRAF2, TRAF5, TRAF7, TRIM27, TRIP13, TRPC6, TSC1, TSC2, TSHR, TTLL5, TUBB1, TUBB3, TWIST2, TXNL4A, TYK2, TYMS, TYRO3, U2AF1, UGT1A1, UMPS, UPF1, USP36, VEGFA, VHL, VTCN1, WAS, WDR72, WEE1, WRN, WT1, WWTR1, XIAP, XPA, XPC, XPO1, XRCC1, XRCC2, XRCC3, YAP1, YES1, ZBTB16, ZBTB2, ZBTB7A, ZFHX3, ZMYM2, ZNF2, ZNF217, ZNF292, ZNF703, ZRSR2