Зонды BCP1100Plus — Расширенная онкологическая панель (1100 генов, 2 Мб), 96 реакций

Панель Homgen BCP1100 Plus предназначена для комплексного анализа мутаций, связанных с опухолевыми заболеваниями, включая генетическую предрасположенность, терапевтические мишени, MSI и мутационную нагрузку. Основана на технологии ProbeCap жидкостной гибридизации и включает более 1000 генов, охватывающих ~2 млн пар оснований. Содержит полные кодирующие регионы 450+ генов, 655 генов с горячими точками мутаций, 50 MSI-локусов, 128 позиций для химиотерапевтических маркеров, 51 интронный регион и 75 SNP для идентификации личности.

Список генов:
A1CF, ABCA4, ABCB1, ABCC2, ABCC8, ABCG2, ABI1, ABL1, ABL2, ABRAXAS1, ACKR3, ACSL3, ACSL6, ACTC1, ACTG1, ACVR1, ACVR1B, ACVR2A, ACYP2, ADGRA2, ADGRG6, ADORA2A, AFDN, AFF1, AFF3, AFF4, AGO2, AJUBA, AKAP9, AKT1, AKT2, AKT3, ALDH2, ALK, ALOX12B, AMER1, ANK1, ANKRD11, ANKRD26, APC, APOBEC3B, AQP7, AR, ARAF, ARFRP1, ARHGAP26, ARHGAP35, ARHGAP5, ARHGEF10, ARHGEF10L, ARHGEF12, ARID1A, ARID1B, ARID2, ARID5B, ARNT, ARSA, ARVCF, ASPM, ASPSCR1, ASXL1, ASXL2, ATAD3B, ATF1, ATIC, ATM, ATP1A1, ATP2B3, ATP6V1B2, ATP7B, ATR, ATRX, ATXN7L1, AURKA, AURKB, AXIN1, AXIN2, AXL, B2M, B9D2, BABAM1, BAP1, BARD1, BAX, BAZ1A, BBC3, BCL10, BCL11A, BCL11B, BCL2, BCL2A1, BCL2L1, BCL2L11, BCL2L12, BCL2L2, BCL3, BCL6, BCL7A, BCL9L, BCLAF1, BCOR, BCORL1, BCR, BEST1, BIRC2, BIRC3, BIRC6, BLM, BMP5, BMPR1A, BRAF, BRCA1, BRCA2, BRD3, BRD4, BRIP1, BTBD9, BTG1, BTG2, BTK, BUB1B, C11orf95, C8orf34, CA12, CALR, CAMTA1, CANT1, CARD11, CARD8, CARM1, CARS, CASP2, CASP3, CASP7, CASP8, CASP9, CBFA2T3, CBFB, CBL, CBLB, CBLC, CBR3, CC2D2A, CCDC6, CCN6, CCNB1IP1, CCNC, CCND1, CCND2, CCND3, CCNE1, CCNH, CCNQ, CCR4, CCR7, CD22, CD274, CD276, CD28, CD58, CD70, CD74, CD79A, CD79B, CDA, CDC42, CDC73, CDH1, CDH10, CDH11, CDH17, CDK12, CDK2, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDRT4, CDX2, CEBPA, CENPA, CEP43, CEP89, CFAP61, CFTR, CHD1, CHD2, CHD4, CHEK1, CHEK2, CHIC2, CHRNA4, CHST11, CIC, CIITA, CLIP1, CLP1, CLSTN2, CLTC, CLTCL1, CNBD1, CNGA1, CNOT3, CNOT4, CNTNAP2, CNTRL, COL1A1, COL2A1, COL3A1, COL4A5, COMT, COP1, CP, CPEB3, CREB1, CREB3L1, CREB3L2, CREBBP, CRKL, CRLF2, CRNKL1, CRTC1, CRTC3, CSDE1, CSF1, CSF1R, CSF2, CSF3, CSF3R, CSMD3, CSNK1A1, CTCF, CTLA4, CTNNA1, CTNNA2, CTNNB1, CTNND1, CTNND2, CTR9, CUBN, CUL3, CUL4A, CUX1, CXCR2, CXCR4, CYLD, CYP17A1, CYP19A1, CYP1A1, CYP1B1, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP4B1, CYP4V2, CYSLTR2, D2S123, DACH1, DAXX, DCAF12L2, DCC, DCTN1, DCUN1D1, DDB2, DDC, DDIT3, DDR1, DDR2, DDX10, DDX3X, DDX41, DDX5, DDX6, DEK, DGCR8, DHFR, DHX15, DICER1, DIS3, DKC1, DNAJB1, DNM2, DNMT1, DNMT3A, DNMT3B, DOT1L, DPYD, DROSHA, DSCAM, DTX1, DUSP22, DUSP4, E2F3, EBF1, ECT2L, EED, EGFL7, EGFR, EIF1AX, EIF3E, EIF4A2, EIF4E, ELAC2, ELF3, ELF4, ELK4, ELL, ELN, ELOC, EMC3, EML4, EMSY, EP300, EP400, EPAS1, EPCAM, EPHA2, EPHA3, EPHA5, EPHA7, EPHB1, EPHB2, EPHB4, EPOR, EPS15, ERBB2, ERBB3, ERBB4, ERC1, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, ERCC8, ERF, ERG, ERICH1, ERRFI1, ESCO2, ESR1, ESR2, ETFA, ETNK1, ETS1, ETV1, ETV4, ETV5, ETV6, EWSR1, EXT1, EXT2, EZH1, EZH2, EZR, FADD, FAM131B, FAM135B, FAM161A, FAM227B, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FAT1, FAT3, FAT4, FBLN2, FBXO11, FBXW7, FCGR2B, FCGR2C, FCGR3A, FCGR3B, FCRL4, FEN1, FES, FGF1, FGF10, FGF12, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4, FGF5, FGF6, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FH, FHIT, FIP1L1, FLCN, FLI1, FLNA, FLT1, FLT3, FLT4, FMO4, FNBP1, FNDC3A, FOXA1, FOXF1, FOXL2, FOXO1, FOXO3, FOXO3B, FOXO4, FOXP1, FOXR1, FRS2, FSTL3, FUBP1, FURIN, FUS, FYN, GAB2, GABRA6, GALNT12, GALT, GAS7, GATA1, GATA2, GATA3, GATA4, GATA6, GEN1, GID4, GLI1, GMPS, GNA11, GNA13, GNAQ, GNAS, GNB1, GOLGA5, GOLPH3, GOPC, GPC3, GPC5, GPS2, GREM1, GRIN2A, GRK3, GRM3, GSE1, GSK3B, GSTM1, GSTM5, GSTP1, GSTT4, H1-2, H2AC11, H2AC16, H2BC4, H3-3A, H3-3B, H3-4, H3-5, H3C1, H3C10, H3C11, H3C12, H3C13, H3C14, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3P4, HAS3, HDAC1, HDAC2, HDAC6, HERPUD1, HEY1, HGD, HGF, HIF1A, HIP1, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-E, HLA-F, HLA-G, HLF, HMGA1, HMGA2, HNF1A, HNRNPA2B1, HNRNPK, HOOK3, HOXA11, HOXA13, HOXA9, HOXB13, HOXC11, HOXC13, HOXD11, HOXD13, HRAS, HSD3B1, HSD3B2, HSP90AA1, HSP90AB1, HSPA4, HSPH1, ICOSLG, ID3, IDH1, IDH2, IDUA, IFNGR1, IGF1, IGF1R, IGF2, IGF2BP3, IGF2R, IKBKB, IKBKE, IKZF1, IKZF3, IL10, IL21R, IL6ST, IL7R, INHA, INHBA, INPP4A, INPP4B, INPPL1, INSR, IRF1, IRF2, IRF4, IRF8, IRS1, IRS2, IRS4, ITGAV, ITK, JAK1, JAK2, JAK3, JARID2, JAZF1, JUN, KANK1, KAT6A, KAT6B, KAT7, KCNA1, KCNJ12, KCNJ5, KCNQ3, KDM5A, KDM5C, KDM6A, KDR, KDSR, KEAP1, KEL, KIF1B, KIF5B, KIT, KLF4, KLHL6, KMT2A, KMT2B, KMT2C, KMT2D, KMT5A, KNL1, KNSTRN, KRAS, KSR2, KTN1, KYAT3, LAMA2, LAMP1, LARP4B, LASP1, LATS1, LATS2, LCK, LCP1, LEF1, LHFPL6, LIFR, LIMD1, LINGO2, LMNA, LMO1, LMO2, LPP, LRIG3, LRP1B, LRP2, LRRC7, LSM14A, LTK, LYL1, LYN, LZTR1, MACC1, MAF, MAFB, MAGI2, MALT1, MAML1, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAP3K1, MAP3K13, MAP3K14, MAP3K4, MAP4K3, MAPK1, MAPK3, MAPKAP1, MAST3, MATN3, MAX, MC1R, MCL1, MDC1, MDM2, MDM4, MECOM, MED12, MEF2B, MEN1, MERTK, MET, MGA, MGAM, MGAT4A, MGST2, MINDY4, MITF, MKNK1, MKS1, MLH1, MLH3, MLLT10, MLLT3, MPL, MRE11, MRO, MS4A1, MSH2, MSH3, MSH4, MSH6, MSI1, MSI2, MST1, MST1L, MST1R, MT1X, MTAP, MTHFD1L, MTHFR, MTOR, MTR, MTRR, MUC1, MUTYH, MYB, MYC, MYCL, MYCN, MYD88, MYH11, MYH9, MYO18B, MYO5A, MYOD1, MYT1L, N4BP2, NAB2, NBN, NBPF19, NBPF20, NCOA3, NCOR1, NCOR2, NCSTN, NDRG1, NEGR1, NF1, NF2, NFAM1, NFATC2, NFE2L2, NFIB, NFKB2, NFKBIA, NFKBIE, NIN, NKX2-1, NKX3-1, NONO, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPC1, NPM1, NPRL3, NQO1, NR4A3, NRAS, NRG1, NSD1, NSD2, NSD3, NT5C2, NTHL1, NTRK1, NTRK2, NTRK3, NUDT15, NUF2, NUP214, NUP93, NUP98, NUTM1, OPRM1, OTC, OTOF, P2RY8, PAFAH1B2, PAK1, PAK3, PAK5, PALB2, PARM1, PARP1, PARP2, PARP3, PAX3, PAX5, PAX7, PAX8, PBRM1, PBX1, PCBP1, PCM1, PDCD1, PDCD1LG2, PDE9A, PDGFB, PDGFRA, PDGFRB, PDHA1, PDK1, PDPK1, PDS5B, PER1, PGR, PHF6, PHOX2B, PIGA, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIM1, PKHD1, PLAG1, PLCG1, PLCG2, PLK1, PLK2, PMAIP1, PMS1, PMS2, PNPLA3, PNRC1, POLD1, POLE, POLH, POLQ, POLR2A, POLR2F, POT1, POU2AF1, POU5F1, PPARG, PPFIBP1, PPM1D, PPP2R1A, PPP2R2A, PPP4R2, PPP6C, PRCC, PRDM1, PRDM14, PRDM16, PRDM2, PREX2, PRF1, PRG4, PRKAA2, PRKACA, PRKAR1A, PRKCI, PRKD1, PRKDC, PRKN, PROM1, PRPF40B, PRRX1, PRSS1, PRSS8, PSIP1, PSMB8, PTCH1, PTCH2, PTEN, PTGS2, PTK2, PTK2B, PTK6, PTP4A1, PTPN1, PTPN11, PTPN2, PTPN6, PTPRB, PTPRC, PTPRD, PTPRK, PTPRO, PTPRS, PTPRT, PWWP2A, PYGL, QKI, RAB35, RAB3GAP2, RABEP1, RAC1, RAC2, RAD17, RAD21, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54B, RAD54L, RAF1, RANBP2, RAP1GDS1, RARA, RB1, RBBP8, RBM10, RBM15, RECQL, RECQL4, REEP5, REL, RELA, RET, RFWD3, RGPD1, RGPD2, RGPD4, RGPD6, RGPD8, RGS7, RHBDF2, RHCE, RHEB, RHOA, RICTOR, RIT1, RNF213, RNF43, ROBO2, ROS1, RPA1, RPL22, RPL5, RPN1, RPS6KA4, RPS6KB1, RPS6KB2, RPTOR, RRAGC, RRAS, RRAS2, RRM1, RSPO2, RSPO3, RSRP1, RTEL1, RUNX1, RUNX1T1, RXRA, RYBP, RYR2, S100A7, S100A8, SALL4, SAMHD1, SBDS, SCD, SCN3B, SDC4, SDHA, SDHAF2, SDHB, SDHC, SDHD, SDK1, SEMA3C, SEMA3E, SEPTIN5, SEPTIN6, SEPTIN9, SERPINB3, SESN1, SESN2, SESN3, SET, SETBP1, SETD1A, SETD1B, SETD2, SETDB1, SF3B1, SFPQ, SFRP4, SGK1, SH2B3, SH2D1A, SH3GL1, SHOC2, SHQ1, SHTN1, SIPA1L2, SIX1, SIX2, SKI, SLC16A6, SLC19A1, SLC22A2, SLC28A3, SLC34A2, SLC3A2, SLC45A3, SLC5A10, SLC7A8, SLCO1B1, SLCO1B3, SLFN11, SLFN12L, SLFN13, SLIT1, SLIT2, SLX4, SMAD2, SMAD3, SMAD4, SMARCA2, SMARCA4, SMARCB1, SMARCD1, SMC1A, SMC3, SMG1, SMO, SMYD3, SNAPC2, SNCAIP, SND1, SNX29, SOCS1, SOD2, SOS1, SOX17, SOX2, SOX21, SOX9, SPECC1, SPEN, SPINK1, SPOP, SPRED1, SPTA1, SRC, SRD5A2, SRGAP3, SRSF2, SRSF3, SS18, SS18L1, STAG1, STAG2, STAT3, STAT4, STAT5A, STAT5B, STAT6, STIL, STIM1, STK11, STK19, STK40, STRN, STT3A, SUB1, SUDS3, SUFU, SUZ12, SV2C, SYK, TAF1, TAF15, TAF1L, TAL1, TAL2, TAP1, TAP2, TBK1, TBL1XR1, TBX3, TCEA1, TCF12, TCF3, TCF4, TCF7L2, TCL1A, TEC, TEK, TENT5C, TERT, TET1, TET2, TET3, TFE3, TFEB, TFG, TFPT, TFRC, TGFBR1, TGFBR2, THADA, TIPARP, TK2, TLK2, TLR4, TLR7, TLR8, TLR9, TLX1NB, TLX3, TMEM127, TMEM67, TMPRSS13, TMPRSS2, TMSB4X, TNC, TNFAIP3, TNFRSF14, TNFRSF17, TNFSF11, TOP1, TOP2A, TP53, TP53BP1, TP63, TPM3, TPM4, TPMT, TPSAB1, TRAF2, TRAF5, TRAF7, TRIM24, TRIM27, TRIM33, TRIP11, TRIP13, TRRAP, TSC1, TSC2, TSHR, TTLL5, TUBB1, TUBB3, TWIST2, TXNL4A, TYK2, TYMS, TYRO3, U2AF1, UBR5, UGT1A3,UGT1A,UGT1A7,UGT1A5,UGT1A4,UGT1A9,UGT1A6,UGT1A10,UGT1A8,UGT1A1,UGT1A5,UGT1A6,UGT1A3,UGT1A1,UGT1A4,UGT1A7,UGT1A9,UGT1A10,UGT1A8, UGT1A3,UGT1A,UGT1A7,UGT1A5,UGT1A4,UGT1A9,UGT1A6,UGT1A8,UGT1A10,UGT1A1,UGT1A5,UGT1A6,UGT1A3,UGT1A1,UGT1A4,UGT1A7,UGT1A9,UGT1A10,UGT1A8, UGT1A4,UGT1A5,UGT1A7,UGT1A,UGT1A3,UGT1A1,UGT1A10,UGT1A8,UGT1A6,UGT1A9,UGT1A5,UGT1A6,UGT1A3,UGT1A1,UGT1A4,UGT1A7,UGT1A9,UGT1A10,UGT1A8, UGT1A5,UGT1A6,UGT1A3,UGT1A1,UGT1A4,UGT1A7,UGT1A9,UGT1A10,UGT1A8,UGT1A6,UGT1A9,UGT1A1,UGT1A8,UGT1A10,UGT1A7,UGT1A3,UGT1A,UGT1A5,UGT1A4, UGT1A5,UGT1A6,UGT1A3,UGT1A1,UGT1A4,UGT1A7,UGT1A9,UGT1A10,UGT1A8,UGT1A9,UGT1A6,UGT1A8,UGT1A10,UGT1A1,UGT1A3,UGT1A,UGT1A7,UGT1A5,UGT1A4, UMPS, UNK, UPF1, USP36, USP8, USP9X, VAV1, VEGFA, VHL, VTCN1, VTI1A, WAS, WDCP, WDR72, WEE1, WIF1, WNK2, WRN, WT1, WWTR1, XIAP, XPA, XPC, XPO1, XRCC1, XRCC2, XRCC3, YAP1, YES1, ZBTB16, ZBTB2, ZBTB7A, ZEB1, ZFHX3, ZMYM2, ZMYM3, ZNF2, ZNF217, ZNF292, ZNF331, ZNF384, ZNF521, ZNF703, ZNRF3, ZRSR2